Table 5. A significant interactive model for CHRNA5/A3/B4 cluster with SI in KARE male sample on the basis of the prediction accuracy and the sign test P value.

No. ofLoci	Best Model	Prediction Accuracy	Sign Test (P)	CVC
5	LOC123688: rs7163730CHRNA3: rs6495308Inter-genic region: rs7166158, rs8043123, rs11072793	0.517	9 (0.011)	10/10

(1) SI  =  smoking initiation; (2) CVC  =  cross-validation consistency; and (3) In GMDR analysis, age and area were used as covariates.