Table 1. Top 15 upregulated genes involved in leptin mediated weight loss.
Symbol | FC_SQa | FC_ICVb | FC_ob/B6c | adj.P.Vald | Definition |
Igfbp2 | 6.54 | 16.10 | 0.06 | 2.10E-08 | insulin-like growth factor binding protein 2 |
Acot1 | 3.12 | 5.60 | 0.65 | 0.000739 | acyl-CoA thioesterase 1 |
Lyz | 2.33 | 4.93 | 0.41 | 0.000107 | Lysozyme |
Mat2a | 2.55 | 4.10 | 0.37 | 0.000703 | methionine adenosyltransferase II, alpha |
Lpl | 2.32 | 4.03 | 0.86 | 0.000211 | lipoprotein lipase (Lpl) |
Pla2g12a | 2.04 | 4.57 | 0.66 | 0.000125 | phospholipase A2, group XIIA |
Wbp5 | 3.01 | 3.44 | 0.35 | 0.000535 | WW domain binding protein 5 |
C1qb | 2.32 | 3.22 | 0.28 | 0.000584 | complement component 1, q subcomponent, beta polypeptide |
H2-Ab1 | 2.52 | 2.88 | 0.50 | 0.001534 | histocompatibility 2, class II antigen A, beta 1 |
Hadhb | 2.04 | 3.17 | 0.99 | 0.000344 | hydroxyacyl-Coenzyme A dehydrogenase |
Egfr | 2.58 | 2.48 | 0.16 | 0.001144 | epidermal growth factor receptor |
Slc25a33 | 2.60 | 2.43 | 0.38 | 0.000271 | solute carrier family 25, member 33 |
Slc40a1 | 2.24 | 2.77 | 0.68 | 0.001166 | solute carrier family 40 (iron-regulated transporter), member 1 |
LOC100046120 | 2.30 | 2.65 | 0.33 | 0.001791 | s musculus similar to clusterin |
Rps11 | 2.12 | 2.52 | 0.38 | 0.001243 | ribosomal protein S11 |
FC_SQ: fold change in gene expression after peripheral (subcutaneous) leptin administration as compared to vehicle subcutaneous treatment.
FC_ICV: fold change in gene expression after central (intracerebroventricular) leptin administration as compared to vehicle intracerebroventricular treatment.
FC_ob/B6: fold change in gene expression in vehicle treated ob/ob mice as compared to the expression in B6 mice.
adj.P.Val: adj. p-value of regression analysis performed to test for a linear association between gene expression levels and amount of weight loss.