Table 1. Top 15 upregulated genes involved in leptin mediated weight loss.

Symbol	FC_SQa	FC_ICVb	FC_ob/B6c	adj.P.Vald	Definition
Igfbp2	6.54	16.10	0.06	2.10E-08	insulin-like growth factor binding protein 2
Acot1	3.12	5.60	0.65	0.000739	acyl-CoA thioesterase 1
Lyz	2.33	4.93	0.41	0.000107	Lysozyme
Mat2a	2.55	4.10	0.37	0.000703	methionine adenosyltransferase II, alpha
Lpl	2.32	4.03	0.86	0.000211	lipoprotein lipase (Lpl)
Pla2g12a	2.04	4.57	0.66	0.000125	phospholipase A2, group XIIA
Wbp5	3.01	3.44	0.35	0.000535	WW domain binding protein 5
C1qb	2.32	3.22	0.28	0.000584	complement component 1, q subcomponent, beta polypeptide
H2-Ab1	2.52	2.88	0.50	0.001534	histocompatibility 2, class II antigen A, beta 1
Hadhb	2.04	3.17	0.99	0.000344	hydroxyacyl-Coenzyme A dehydrogenase
Egfr	2.58	2.48	0.16	0.001144	epidermal growth factor receptor
Slc25a33	2.60	2.43	0.38	0.000271	solute carrier family 25, member 33
Slc40a1	2.24	2.77	0.68	0.001166	solute carrier family 40 (iron-regulated transporter), member 1
LOC100046120	2.30	2.65	0.33	0.001791	s musculus similar to clusterin
Rps11	2.12	2.52	0.38	0.001243	ribosomal protein S11

^aFC_SQ: fold change in gene expression after peripheral (subcutaneous) leptin administration as compared to vehicle subcutaneous treatment.

^bFC_ICV: fold change in gene expression after central (intracerebroventricular) leptin administration as compared to vehicle intracerebroventricular treatment.

^cFC_ob/B6: fold change in gene expression in vehicle treated ob/ob mice as compared to the expression in B6 mice.

^dadj.P.Val: adj. p-value of regression analysis performed to test for a linear association between gene expression levels and amount of weight loss.