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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Metab Eng. 2010 May 27;12(5):429–445. doi: 10.1016/j.ymben.2010.05.003

Table II.

Linear Physical Programming optimization results for a tri-objective system (NADPH synthesis, albumin synthesis and urea synthesis) for hepatic metabolic network. HUD is highly undesirable, UD is undesirable, T is tolerable, D is desirable and HD is highly desirable preference values of objective functions.

Case
#
Priority Flux t1
(HD)
t2
(D)
t3
(T)
t4
(UD)
t5
(HUD)
Optimal
1 High Urea 34.869 31.818 28.767 25.716 22.665 23.724
High NADPH 3.504 3.198 2.891 2.585 2.278 2.278
High Albumin 0.143 0.130 0.118 0.105 0.093 0.130
2 High Urea 34.869 33.125 31.382 29.638 27.895 29.706
Low NADPH 0.100 0.078 0.055 0.033 0.010 0.100
High Albumin 0.143 0.135 0.128 0.121 0.114 0.135
3 High Urea 34.869 33.125 31.382 29.638 27.895 34.845
Low NADPH 0.100 0.078 0.055 0.033 0.010 0.311
Low Albumin 1.00·10−3 7.53·10−4 5.05·10−4 2.58·10−4 1.00·10−5 0.001
4 Low Urea 1.000 0.750 0.500 0.250 1.00·10−5 1
High NADPH 3.504 3.329 3.154 2.979 2.804 3.442
High Albumin 0.143 0.135 0.128 0.121 0.114 0.143
5 Low Urea 1.000 0.750 0.500 0.250 1.00·10−5 4.39
High NADPH 3.504 3.329 3.154 2.979 2.804 3.504
Low Albumin 1.00·10−3 7.53·10−4 5.05·10−4 2.58·10−4 1.00·10−5 0.100
6 Low Urea 1.000 0.750 0.500 0.250 1.00·10−5 1
Low NADPH 0.100 0.078 0.055 0.033 0.010 0.100
High Albumin 0.143 0.135 0.128 0.121 0.114 0.143