Table 1.
Summary of glioma families studied
| Index case | Other family members | |||||
|---|---|---|---|---|---|---|
| Family ID | Origin | Sex/age | Pathology | Relation | Sex/age | Pathology |
| 1 | USA | F/48 | O | brother | M/33 | A |
| pat. first cousin | F/20 | E | ||||
| 2 | USA | F/42 | O | brother | M/32 | AA |
| 3 | USA | M/43 | GBM | sister | F/16 | A |
| 4 | USA | F/40 | A | pat. first cousin | F/30 | O |
| 5 | USA | M/51 | GBM | father | M/68 | GBM |
| 6 | USA | M/40 | AA | brother | M/46 | GBM |
| sister | F/16 | A | ||||
| brother | M/45 | MEL | ||||
| 7 | USA | F/54 | GBM | pat. uncle | M/57 | GBM |
| pat. first cousin | M/51 | GBM | ||||
| 8 | USA | M/56 | GBM | sister | F/65 | GBM |
| sister | F/53 | GBM | ||||
| 9 | USA | M/77 | GBM, CRC | pat. half-sister | F/68 | GBM |
| pat. half-brother | M/66 | AO | ||||
| 10 | USA | F/42 | GBM | brother | M/42 | A |
| 11 | USA | F/54 | GBM | pat. aunt | F/55 | GBM |
| 12 | USA | F/27 | AA | brother | M/43 | AO |
| sister | F/43 | AA | ||||
| 13 | USA | F/22 | E | mat. grand aunt | F/61 | GBM |
| 14 | USA | F/27 | O | brother | M/39 | AA |
| 15 | USA | F/52 | GBM | brother | M/61 | GBM |
| 16 | USA | M/41 | GBM | pat. grandmother | F/52 | A |
| 17 | USA | M/57 | GBM | brother | M/46 | OA |
| sister | F/64 | Men, MEL | ||||
| 18 | USA | M/59 | GBM | mat. uncle | M/80 | GBM |
| mat. first cousin, twice removed | M/60 | GBM | ||||
| 19 | USA | M/77 | GBM | nephew | M/40 | AA |
| 20 | USA | F/34 | OA | mother | F/41 | GBM |
| mat. first cousin, once removed | F/59 | GBM | ||||
| mat. aunt | F/45 | G-U | ||||
| 21 | USA | F/56 | GBM | nephew | M/13 | GBM |
| 22 | USA | M/28 | OA | mother | F/60 | GBM |
| 23 | USA | F/26 | GBM | father | M/45 | GBM |
| 24 | USA | F/36 | GBM | mat. first cousin | M/17 | O |
| 25 | USA | F/66 | GBM | father | M/70 | GBM, LC |
| grandson | M/5 | NE | ||||
| 26 | USA | M/49 | AA | father | M/51 | GBM |
| son | M/28 | AO | ||||
| 27 | USA | F/44 | GBM | mother | F/32 | A |
| 28 | USA | F/51 | A, GBM | brother | M/41 | AO |
| 29 | USA | F/42 | GBM | pat. grandfather | M/79 | A |
| pat. first cousin, once removed | F/49 | A | ||||
| 30 | USA | F/19 | A | mother | F/33 | O |
| 31 | USA | F/80 | GBM | brother | M/63 | GBM |
| 32 | USA | F/36 | PA | son | M/11 | A |
| 33 | USA | M/53 | GBM | sister | F/40 | OA |
| 34 | USA | M/65 | AO | mat. aunt | F/82 | GBM |
| mat. first cousin, once removed | F/61 | GBM | ||||
| mat. grand aunt | F/81 | AA | ||||
| mat. grand aunt | F/79 | GBM | ||||
| mat. first cousin, once removed | F/63 | G-U | ||||
| 35 | USA | F/39 | A | mat. aunt | F/66 | GBM |
| 36 | USA | M/38 | A | mat. grandfather | M/58 | GBM |
| mat. grand aunt | F/75 | GBM | ||||
| 37 | USA | M/48 | OA | brother | M/40 | O |
| 38 | USA | M/29 | OA | father | M/60 | AO |
| 39 | USA | M/43 | O | brother | M/32 | O |
| grand niece | F/7 | PA | ||||
| 40 | USA | F/45 | OA | mat. aunt | F/30 | G-U |
| mat. grandmother | F/31 | G-U | ||||
| 41 | USA | M/64 | A | niece | F/32 | A |
| 42 | USA | F/30 | AA | brother | M/12 | E |
| 43 | USA | M/66 | GBM | brother | M/53 | GBM |
| brother | M/54 | LEU | ||||
| 44 | USA | F/43 | A | mother | F/27 | A |
| brother | M/45 | GBM | ||||
| 45 | USA | M/54 | O | sister | F/52 | GBM |
| 46 | USA | F/74 | A | sister | F/82 | GBM |
| mother | F/65 | G-U | ||||
| 47 | USA | F/16 | PA | mat. first cousin | M/6 | PA |
| 48 | USA | M/68 | GBM | daughter | F/35 | GBM |
| 49 | USA | F/5 | G-U | mat. aunt | F/10 | AA |
| mat. first cousin, once removed | F/1 | G-U | ||||
| 50 | USA | F/6 | A | father | M/64 | GBM |
| 51 | USA | M/28 | AA | mz twin | M/18 | OA |
| 52 | USA | F/53 | AO | mat. first cousin | M/53 | AA |
| 53 | USA | M/42 | A, O | brother | M/29 | A |
| mat.uncle | M/38 | A | ||||
| 54 | USA | M/48 | O | father | M/55 | OA |
| 55 | USA | F/68 | GBM | sister | F/60 | A |
| brother | M/58 | Men | ||||
| 56 | USA | F/28 | O | mat. aunt | F/49 | GBM |
| 57 | USA | F/51 | O | brother | M/38 | GBM |
| brother | M/49 | O | ||||
| 58 | USA | F/53 | GBM | mat. uncle | M/58 | GBM |
| 59 | USA | F/55 | A | sister | F/47 | AA |
| 60 | USA | F/37 | GBM | sister | F/32 | A |
| 61 | USA | F/73 | GBM | sister | F/45 | OA |
| father | M/64 | AA | ||||
| 62 | USA | M/56 | OA | mother | F/83 | GBM |
| 63 | USA | F/35 | AE | father | M/53 | GBM |
| 64 | USA | M/68 | GBM | pat. first cousin | M/55 | GBM |
| 65 | USA | M/66 | GBM | brother | M/71 | GBM |
| 66 | Denmark | F/45 | A | brother | M/37 | GBM |
| 67 | Denmark | M/25 | A | father | M/39 | O |
| pat. half aunt | F/60 | GBM | ||||
| 68 | Denmark | F/30 | A | mat. first cousin, once removed | F/37 | GBM |
| mat. grand uncle | M/34 | A | ||||
| mat. grand uncle | M/75 | GBM | ||||
| 69 | Denmark | F/51 | A | brother | M/41 | A |
| 70 | Denmark | F/35 | GBM | pat. grand aunt | F/50 | GBM |
| 71 | Sweden | F/60 | AE | mother | F/70 | A |
| brother | M/39 | A | ||||
| 72 | Sweden | F/46 | AA | nephew | M/9 | A |
| 73 | Sweden | M/46 | OA | mat. uncle | M/51 | GBM |
| 74 | Sweden | F/50 | O | pat. uncle | M/57 | GBM |
| pat. first cousin | M/60 | GBM | ||||
| pat. first cousin | F/66 | GBM | ||||
| 75 | Sweden | F/54 | GBM | pat. uncle | M/48 | GBM |
| 76 | Sweden | F/34 | GBM | mother | F/48 | GBM |
| 77 | Denmark | M/58 | AA | father | M/40 | GCG |
| 78 | Denmark | M/64 | GBM | father | M/61 | O |
| son | M/2 | ADR | ||||
| 79 | Israel | M/0.5 | ONG | sister | F/16 | GBM |
| 80 | Israel | F/36 | A | mother | F/40 | A |
| 81 | Israel | F/47 | O | son | M/27 | GBM |
| mother | F/59 | MEL | ||||
| 82 | Sweden | F/31 | A | father | M/63 | GBM |
| 83 | Denmark | F/69 | GBM | brother | M/65 | GBM |
| pat. uncle | M/67 | GBM, PC | ||||
| 84 | Denmark | F/56 | O | son | M/27 | A |
| pat. first cousin | M/42 | O, GBM | ||||
| mat. first cousin | F/56 | Men | ||||
| 85 | Denmark | M/46 | GBM | pat. first cousin | M/58 | AA |
| 86 | Denmark | F/29 | A | pat. first cousin | F/29 | A |
| pat. great aunt | F/58 | AO | ||||
| pat. first cousin once removed | F/37 | GBM | ||||
| 87 | Denmark | M/80 | GBM | father | M/59 | O |
| pat. second cousin | M/46 | A | ||||
| 88 | Denmark | F/67 | AO | brother | M/63 | AO |
| 89 | Denmark | F/47 | GBM | father | M/68 | GBM |
| mat. aunt | F/56 | BC | ||||
| mat. aunt | F/39 | BC | ||||
| mat. first cousin | M/30 | SAR | ||||
| 90 | Denmark | M/69 | A | mother | F/58 | GBM |
| 91 | Denmark | M/77 | GBM | brother | M/69 | GBM |
| mat. aunt | F/73 | A | ||||
| 92 | Denmark | F/53 | GBM | pat. first cousin | M/31 | OA, AO |
| 93 | Denmark | M/43 | AO | mat. first cousin | M/39 | GBM |
| 94 | Denmark | M/44 | O | mat. grandfather | M/74 | AO |
| 95 | Denmark | F/43 | GBM | pat. grandfather | M/58 | GBM |
| 96 | Denmark | F/38 | O | father | M/46 | GBM |
| 97 | Denmark | M/37 | O | father | M/68 | AO |
| 98 | Israel | F/73 | GBM | sister | F/68 | GBM |
| 99 | Israel | F/42 | AA | mat. second cousin | F/2 | PA |
| 100 | Israel | M/58 | GBM | sister | F/58 | GBM |
| brother | M/64 | GBM | ||||
| 101 | Israel | M/54 | O | mat. aunt | F/72 | GBM |
Age: age at diagnosis.
Pathology: A, astrocytoma; AA, anaplastic astrocytoma; AO, anaplastic oligodendroglioma: AE, anaplastic ependymoma; BC, breast cancer; CRC, colorectal cancer; GBM, glioblastoma multiforme; G-U, glioma unclassified; GCG, giant cell glioblastoma; E ependymoma; LEU, leukemia; LG, lung cancer; O, oligodendroglioma: OA, mixed oligoastrocytoma; ONG, optic nerve glioma; MEL, melanoma; Men, Meningioma; NE, neuroectodermal; PA, pilocytic astrocytoma; PC, pancreatic cancer; SAR, sarcoma.