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. 2010 Aug 15;24(16):1787–1801. doi: 10.1101/gad.1957510

Figure 4.

Figure 4.

Activity of Ligatin, MCT-1, and DENR in 48S complex formation on HCV-like IRESs. (A) Secondary structures of HCV, CSFV, and SPV9 IRESs, with domain II in bold. (B–F) Toe-printing analysis of 48S complex formation on HCV (B), CSFV (C), ΔII CSFV, (D,E) and SPV9 (F) IRESs in the presence of 40S subunits, aminoacylated and deacylated tRNAMeti, Ligatin, MCT-1, DENR, eIF2, and other eIFs as indicated. Initiation codons and positions of assembled ribosomal complexes are indicated. Lanes C, T, A, and G depict corresponding DNA sequences.