Fig. 5.

ALPI-inhibitor ameliorates protective effects of RvE1 in DSS-induced murine colitis.(A) Oral administration of L-Phe, significantly inhibited tissue alkaline phosphatase activity. (B) Weight loss curves indicate that DSSPhe and DSS??Phe both lost significantly more weight during the time course than vehiclePhe-treated animals. (C) DAI scores indicate that L-Phe-treated DSS? mice disease severity was significantly different from vehicle mice (P < 0.05). (D) Mesoscale analysis of tissue cytokine levels revealed an increased IL-1β, KC, and IL-12 in DSS, which was reduced by RvE1 in all cases (not significant for IL-12). L-Phe increased the cytokine concentration in DSS and DSS? treated animals (*P < 0.05, **P < 0.01, ***P < 0.005).