Table 1.
Candidate inhibitory drug targets for modulation of autophagy in neurodegenerative disease
| Gene symbol | Gene ID | Gene name |
| Drug targets for up-regulation of autophagy | ||
| PPFIA4 | 8497 | Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 |
| ADMR | 11318 | Adrenomedullin receptor |
| PTGER2 | 5732 | Prostaglandin E receptor 2 (subtype EP2), 53kDa |
| EP300 | 2033 | E1A binding protein p300 |
| CXCL12 | 6387 | Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) |
| NCR3 | 259197 | Natural cytotoxicity triggering receptor 3 |
| GABBR2 | 9568 | Gamma-aminobutyric acid (GABA) B receptor, 2 |
| GJA4 | 2701 | Gap junction protein, alpha 4, 37kDa |
| KRT18 | 3875 | Keratin 18 |
| SDHB | 6390 | Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
| GTF2IRD2 | 84163 | GTF2I repeat domain containing 2 |
| GNRH2 | 2797 | Gonadotropin-releasing hormone 2 |
| HIVEP2 | 3097 | HIV type I enhancer binding protein 2 |
| USP19 | 10869 | Ubiquitin specific peptidase 19 |
| EPHA6 | 203806 | EPH receptor A6 |
| TACR2 | 6865 | Tachykinin receptor 2 |
| MYL3 | 4634 | Myosin, light chain 3, alkali; ventricular, skeletal, slow |
| CAPN1 | 823 | Calpain 1, (mu/I) large subunit |
| SORCS2 | 57537 | Sortilin-related VPS10 domain containing receptor 2 |
| BAIAP2 | 10458 | BAI1-associated protein 2 |
| THBS2 | 7058 | Thrombospondin 2 |
| PCGF1 | 84759 | Polycomb group ring finger 1 |
| MMP10 | 4319 | Matrix metallopeptidase 10 (stromelysin 2) |
| CHRND | 1144 | Cholinergic receptor, nicotinic, delta |
| CDKN2D | 1032 | Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) |
| FBXL20 | 84961 | F-box and leucine-rich repeat protein 20 |
| Drug targets for down-regulation of autophagy | ||
| ATG7 | 10533 | ATG7 autophagy related 7 homolog (S. cerevisiae) |
| MEGF10 | 84466 | Multiple EGF-like-domains 10 |
| KIF5C | 3800 | Kinesin family member 5C |
| SMYD3 | 64754 | SET and MYND domain containing 3 |
| LOC285647 | 285647 | Suppressor of defective silencing 3 pseudogene |
| STIM1 | 6786 | Stromal interaction molecule 1 |
| GAB1 | 2549 | GRB2-associated binding protein 1 |
| GPR18 | 2841 | G-protein–coupled receptor 18 |
| CATSPER4 | 378807 | Cation channel, sperm associated 4 |