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Model of GABA neuron death induced by CoQ depletion. Reduced CoQ (Q) function in mitochondria activates an unknown signal that may evoke CRT-1–dependent (calreticulin) Ca2+ release from the endoplasmic reticulum. GABA neuron degeneration requires CED-4 and at least one additional downstream pathway that functions in parallel to CED-3 (caspase). DRP-1, a dynamin-related protein that drives mitochondrial fission, is also required for degeneration in CoQ-depleted GABA neurons.
