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. 2010 Jul 26;107(32):14280–14285. doi: 10.1073/pnas.1009559107

Fig. 1.

Fig. 1.

BRD7 depletion increases proliferation and delays senescence in primary fibroblasts. (A) Population-doubling (PD) curves in primary BJ fibroblasts (Upper) and BJs expressing the HPV E7 oncoprotein (Lower) and the indicated shRNAs. (B) Senescence-associated β-galactosidase staining quantification with error bars indicating SEM in primary human BJ fibroblasts infected with retroviruses expressing the indicated shRNAs. (C) BRD7 depletion measured by Western blot in primary human BJ fibroblasts infected with retroviruses expressing the indicated shRNAs. (D) Senescence-associated β-galactosidase staining quantification on day 16 posttransduction with RasV12D or vector alone; error bars indicate SEM. Population doublings in human BJ fibroblasts were measured on day 15 posttransduction with RasV12D or vector alone in primary BJ fibroblasts expressing the indicated shRNAs.