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. 2010 Jul 21;107(32):14093–14098. doi: 10.1073/pnas.1002713107

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Fig. 4. — Effect of double-stapling on pharmacokinetic behavior, acid protease resistance, and oral absorption. (A) Plasma concentrations of intact SAH-gp41_(626–662)(A, B) and T649v in mice treated by intravenous bolus injection. (B) CD revealed that SAH-gp41_(626–662)(A, B) exhibits even greater α-helicity at pH 2, surpassing T649v. (C) Upon exposure to pepsin at pH 2, T649v was rapidly degraded but SAH-gp41_(626–662)(A, B) was strikingly resistant. (D) Orally administered SAH-gp41_(626–662)(A, B) achieved measurable and dose-dependent plasma concentrations, whereas T649v was not detectable. Plasma concentration, mean ± s.d.; fraction intact, mean ± s.d.