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Thiopurines and their metabolism to form 6-thioguanine nucleotides. HPRT, hypoxanthine phosphoribosyltransferase; IMPD, inosine monophosphate dehydrogenase; GMPS, guanosine monophosphate synthase; SGMP, 6-thioguanosine monophosphate; dSGTP, 6-thio-2′-deoxyguanosine triphosphate.
