TABLE 3.
Number and Density of Synaptic Vesicles per Profile (N/µm2), Number of Docked Synaptic Vesicles (N/µm), and Length of the Active Zone (Postsynaptic Density; in nm) in YFP-Identified Retinotectal Synapses in Controls and BDNF-Treated Tadpoles1
| Control | BDNF 8 hours | BDNF 24 hours | |
|---|---|---|---|
| Mature synaptic profiles (%) | 46.3 ± 4.2 | 40.43 ± 4.35 | 60.25 ± 3.92 |
| Synaptic vesicle number | 66.95 ± 11.13 | 63.49 ± 5.1 | 68.39 ± 4.5 |
| Synaptic vesicle density (per µm) | 18.8 ± 2.9 | 19.54 ± 3.052 | 22.25 ± 2.85 |
| Number of docked vesicles | 6.46 ± 0.46 | 7.423 ± 0.58 | 8.15 ± 0.523 |
| Length of active zone (nm) | 206 ± 10 | 290 ± 194 | 225 ± 12 |
1
Number of YFP-immunopositive synaptic profiles analyzed for each individual treatment is n = 80 for controls, n = 69 for BDNF 8 hours, and n = 71 for BDNF 24 hours. One-way ANOVA was used for the statistical analysis of data.
2
P = 0.049 compared with controls.
3
P = 0.0162 compared with controls.
4
P = 0.0046 compared with BDNF 24 hours and P < 0.0001 compared with controls.