. Author manuscript; available in PMC: 2010 Nov 1.

Published in final edited form as: J Periodontol. 2009 Nov;80(11):1731–1741. doi: 10.1902/jop.2009.090236

Table 4.

Change in Hazard of Pre-term Delivery Associated with Change in the Serum Biomarkers

	Adjusted Hazard Ratio for Preterm Delivery (95% Confidence Interval)^*
	Baseline	29–32 weeks	Change from Baseline
CRP	0.70 (0.40, 1.27)^†	1.09 (0.52, 2.36)	1.36 (0.60, 3.06)
PGE₂	1.08 (0.66, 1.86)	0.78 (0.43, 1.52)	0.64 (0.37, 1.13)
MMP-9	0.59 (0.24, 1.45)	0.58 (0.24, 1.43)	1.05 (0.35, 3.16)
Fibrinogen	0.72 (0.25, 2.03)	1.68 (0.51, 5.53)	1.28 (0.48, 3.53)
Endotoxin	0.90 (0.70, 1.14)	0.86 (0.64, 1.12)	0.95 (0.79, 1.15)

Adjusted for clinic, race/ethnicity, age and BMI. Hazards for 29–32 week data and change from baseline also adjusted for periodontal treatment group.

^†

Hazard ratios and confidence limits refer to a 10-fold (one log base 10 unit) increase in the level of the biomarker, except for endotoxin, where they refer to a one-step change in the endotoxin scale.