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Plasma levels of nicotine and its metabolites in male Japanese smokers phenotyped for the CYP2A6 gene. Individuals were grouped in either group 1, CYP2A6*1/*1 (n = 19); group 2, CYP2A6*1/*4, *7, *9, *10 (n = 42); group 3, CYP2A6*4, *7, *9, *10/*7, *9, *10 (n = 24); and group 4, CYP2A6*4/*4 (n = 2). Information on phenotype was not obtained from five subjects. Circles represent individual data and lines denote group means. ***, Significantly different compared with group 1 (p < 0.001).
