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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Radiat Res. 2010 Feb;173(2):214–224. doi: 10.1667/RR1985.1

Table 3.

Analysis of interaction between the 27 Cancer Genetic Markers of Susceptibility and Breast Cancer Association Consortium breast cancer SNPs and radiation dose from occupation and dose score from personal diagnostic x-rays in US Radiologic Technologists study

Gene Entrez SNP
IDa 		Genotype Cases
(%)
(n=859)b 		Controls
(%)
(n=1083)b 		Occupational radiation effect
modification		 Diagnostic radiation effect modification
EOR/Gyc 95%
Confidence
Interval		 p-valued EOR/unit
breast dose
scorec 		95% Confidence
Interval		 p-valued
LSP1 rs3817198 TT 395 (47) 483 (45) 0.6 <0, 8.7 >0.5 1.5 <0, 6.3 >0.5
CT 353 (42) 471 (43) 3.2 <0, 11.4 1.8 <0, 6.8
CC
  		89 (11)
 		 129 (12)
 		 5.8
 		 <0, 34.4
 		 <0
 		 <0, 9.1
 
TT 395 (47) 483 (45) 0.6 <0, 8.7 0.4 1.4 <0, 6.2 >0.5
CT/CC 442 (53) 600 (55) 3.6 <0, 11.3 1.3 <0, 5.4
LOC728873 rs4132417 AA 518 (66) 628 (63) 1.4 <0, 7.6 0.2 0.6 <0, 3.8 >0.5
AT 237 (30) 326 (32) 10.5 0.6, 31.1 2.5 <0, 10.2
TT
  		26 (3)
 		 50 (5)
 		 18.9
 		 <0, 156.2
 		 5.0
 		 <0, 39.2
 
AA 518 (66) 628 (63) 1.4 <0, 7.6 0.07 0.6 <0, 3.8 0.4
AT/TT 263 (34) 376 (37) 11.5 1.4, 31.4 2.9 <0, 10.1
STXBP4 rs6504950 GG 434 (56) 506 (51) 2.1 <0, 11.2 0.03 2.9 <0, 8.0 0.3
AG 299 (38) 426 (43) 2.4 <0, 10.7 <0 <0, 3.2
AA
  		47 (6)
 		 70 (7)
 		 72.1
 		 11.2, 313.0
 		 0.4
 		 <0, 9.4
 
GG 434 (56) 506 (51) 2.0 <0, 11.0 0.5 2.9 <0, 8.0 0.1
AG/AA 580 (74) 740 (74) 5.1 <0, 15.2 <0 <0, 3.0
SLC4A7 rs4973768 GG 200 (26) 265 (26) 7.8 <0, 25.0 >0.5 1.2 <0, 7.9 0.1
AG 378 (48) 491 (49) 3.7 <0, 14.5 3.9 0.2, 10.4
AA
  		202 (26)
 		 249 (25)
 		 1.3
 		 <0, 10.7
 		 <0
 		 <0, 2.3
 
GG 200 (26) 265 (26) 7.6 <0, 24.7 0.3 1.2 <0, 7.8 >0.5
AG/AA 580 (74) 740 (74) 2.4 <0, 9.6 1.4 <0, 5.1
NEK10 rs724244 GG 418 (54) 524 (53) 7.7 0.9, 19.8 0.1 1.5 <0, 5.8 0.4
AG 302 (39) 397 (40) 0.9 <0, 9.2 1.6 <0, 7.3
AA
  		56 (7)
 		 73 (7)
 		 <0
 		 <0, 6.0
 		 <0
 		 <0, 4.7
 
GG 418 (54) 524 (53) 7.4 0.7, 19.4 0.05 1.5 <0, 5.8 >0.5
AG/AA 358 (46) 470 (47) <0 <0, 5.5 0.7 <0, 5.0
GNAT3 rs37936 TT 283 (36) 355 (36) 2.6 <0, 12.8 >0.5 <0 <0, 3.0 0.3
CT 364 (47) 496 (50) 3.7 <0, 14.2 3.4 <0, 9.4
CC
  		132 (17)
 		 144 (14)
 		 0.9
 		 <0, 13.7
 		 1.1
 		 <0, 9.9
 
TT 283 (36) 355 (36) 2.5 <0, 1.9 >0.5 <0 <0, 3.0 0.1
CT/CC 496 (64) 640 (64) 2.7 <0, 10.7 2.7 <0, 7.3
MRPS30 rs930395 GG 430 (56) 603 (61) 0.4 <0, 7.8 >0.5 <0 <0, 1.9 0.1
AG 293 (38) 351 (35) 4.6 <0, 15.9 3.9 0.2, 10.5
AA
  		49 (6)
 		 39 (4)
 		 2.7
 		 <0, 44.1
 		 1.6
 		 <0, 24.9
 
GG 430 (56) 603 (61) 0.4 <0, 7.9 0.3 <0 <0, 1.9 0.04
AG/AA 342 (44) 390 (39) 4.2 <0, 14.4 3.4 0.2, 9.2
MRPS30 rs10941679 AA 395 (51) 574 (58) 0.2 <0, 7.9 0.5 <0 <0, 2.2 0.09
AG 307 (40) 373 (37) 2.4 <0, 12.2 2.8 <0, 8.4
GG
  		71 (9)
 		 50 (5)
 		 10.5
 		 <0, 61.8
 		 13.4
 		 <0, 87.6
 
AA 395 (51) 574 (58) 0.4 <0, 8.2 0.4 <0 <0, 2.1 0.05
AG/GG 378 (49) 423 (42) 3.8 <0, 13.5 3.4 0.2, 8.9
MRPS30 rs2067980 AA 530 (68) 712 (72) 2.1 <0, 9.2 0.3 0.5 <0, 3.7 0.4
AG 216 (28) 257 (26) 2.3 <0, 14.5 2.0 <0, 8.8
GG
  		29 (4)
 		 26 (3)
 		 47.2
 		 <0, 445.9
 		 22.2
 		 <0, 326.4
 
AA 530 (68) 712 (72) 2.2 <0, 9.3 >0.5 0.5 <0, 3.7 0.4
AG/GG 245 (32) 283 (28) 4.2 <0, 18.0 2.8 <0, 9.9
MRPS30 rs4415084 CC 252 (32) 373 (38) <0 <0, 5.0 0.1 <0 <0, 2.1 0.2
CT 358 (46) 467 (47) 2.2 <0, 10.4 2.5 <0, 7.5
TT
  		166 (21)
 		 152 (15)
 		 8.9
 		 <0, 34.7
 		 2.5
 		 <0, 13.2
 
CC 252 (32) 373 (38) <0 <0, 5.1 0.09 <0 <0, 2.2 0.06
CT/TT 524 (68) 619 (62) 3.8 0.9, 12.0 2.5 <0, 6.7
RHBDF2 rs11077820 AA 303 (39) 406 (41) 0.4 <0, 8.1 0.3 0.6 <0, 4.8 >0.5
AG 353 (46) 440 (44) 2.9 <0, 12.5 1.5 <0, 6.3
GG
  		118 (15)
 		 148 (15)
 		 11.5
 		 <0, 39.9
 		 3.0
 		 <0, 17.9
 
AA 303 (39) 406 (41) 0.4 <0, 8.1 0.3 0.6 <0, 4.8 >0.5
AG/GG 471 (61) 588 (59) 4.9 <0, 14.4 1.8 <0, 6.2
PPFIBP2 rs7121523 GG 527 (68) 668 (67) 1.7 <0, 8.7 >0.5 0.3 <0, 3.4 0.3
AG 223 (29) 301 (30) 3.7 <0, 15.5 2.5 <0, 9.4
AA
  		21 (3)
 		 25 (3)
 		 8.7
 		 <0, 285.8
 		 16.0
 		 <0, 133.9
 
GG 527 (68) 668 (67) 1.6 <0, 8.6 >0.5 0.3 <0, 3.4 0.2
AA/AG 244 (32) 326 (33) 3.9 <0, 15.6 3.5 <0, 10.6
CD82 rs7936636 CC 442 (57) 553 (56) 4.2 <0, 12.9 0.3 0.4 <0, 3.7 >0.5
CT 301 (39) 376 (38) 0.8 <0, 10.9 2.5 <0, 9.0
TT
  		37 (5)
 		 64 (6)
 		 <0
 		 <0, 13.2
 		 4.7
 		 <0, 27.1
 
CC 442 (57) 553 (56) 4.2 <0, 12.9 0.3 0.4 <0, 3.7 0.3
CT/TT 338 (43) 440 (44) 0.2 <0, 8.7 2.9 <0, 8.8
C6ORF190 rs9491859 GG 311 (40) 391 (39) 1.3 <0, 10.0 0.2 <0 <0, 1.9 0.1
GT 366 (47) 460 (46) 5.4 <0, 16.3 3.7 0.2, 9.7
TT
  		102 (13)
 		 140 (14)
 		 <0
 		 <0, 5.5
 		 0.5
 		 <0, 9.3
 
GG 311 (40) 391 (39) 1.4 <0, 10.3 >0.5 <0 <0, 1.9 0.04
GT/TT 468 (60) 600 (61) 3.4 <0, 11.8 2.9 0.07, 7.5
LOC647121 rs11249433 AA 271 (35) 388 (39) <0 <0, 8.2 0.4 2.8 <0, 9.2 0.4
AG 371 (48) 443 (45) 3.4 <0, 11.7 <0 <0, 3.4
GG
  		132 (17)
 		 158 (16)
 		 10.5
 		 <0, 44.3
 		 3.4
 		 <0, 14.3
 
AA 271 (35) 388 (39) <0 <0, 7.8 0.3 2.8 <0, 9.2 0.4
AG/GG 503 (65) 601 (61) 4.1 <0, 12.5 0.7 <0, 4.1
TRIT1 rs17570439 AA 476 (61) 607 (61) 2.2 <0, 9.6 >0.5 0.9 <0, 4.9 >0.5
AG 258 (33) 344 (35) 5.5 <0, 20.9 1.8 <0, 7.6
GG
  		43 (6)
 		 45 (5)
 		 <0
 		 <0, 21.7
 		 1.6
 		 <0, 19.4
 
AA 476 (61) 607 (61) 2.1 <0, 9.3 >0.5 0.9 <0, 4.9 >0.5
AG/GG 301 (39) 389 (39) 3.8 <0, 15.8 1.8 <0, 6.8
PRDM10 rs2303659 GG 723 (93) 920 (93) 3.2 <0, 10.5 >0.5 1.3 <0, 4.5 >0.5
AG 54 (7) 74 (7) 0.1 <0, 18.1 1.4 <0, 16.4
RAD51L1 rs10483813 TT 459 (59) 571 (58) 2.3 <0, 9.4 0.1 1.9 <0, 6.2 0.5
AT 275 (35) 358 (36) 1.5 <0, 12.2 <0 <0, 3.9
AA
  		43 (6)
 		 62 (6)
 		 63.1
 		 2.8, 322.1
 		 5.9
 		 <0, 39.7
 
TT 459 (59) 571 (58) 2.1 <0, 8.9 >0.5 1.9 <0, 6.2 0.4
AT/AA 318 (41) 420 (42) 3.4 <0, 15.9 <0 <0, 4.4
CEBPG rs12608723 AA 573 (74) 736 (74) 2.3 <0, 9.1 0.5 0.06 <0, 3.2 0.2
AG 191 (25) 239 (24) 6.2 <0, 26.1 5.6 0.2, 17.3
GG
  		15 (2)
 		 17 (2)
 		 <0
 		 <0, 42.0
 		 1.1
 		 <0, 46.2
 
AA 573 (74) 736 (74) 2.3 <0, 9.0 >0.5 0.07 <0, 3.2 0.1
AG/GG 206 (26) 256 (26) 4.7 <0, 21.9 4.8 0.07, 14.9
TMTC2 rs17740709 AA 501 (64) 612 (62) 4.0 <0, 12.8 0.05 0.4 <0, 3.7 0.5
AG 250 (32) 339 (34) <0 <0, 6.4 3.6 <0, 11.2
GG
  		27 (3)
 		 41 (4)
 		 106.6
 		 5.1, 1215.0
 		 <0
 		 <0, 41.6
 
AA 501 (64) 612 (62) 4.0 <0, 12.7 0.3 0.4 <0, 3.7 0.3
AG/GG 277 (36) 380 (38) 0.2 <0, 8.9 3.4 <0, 10.5
CLEC16A rs998592 CC 268 (34) 313 (31) 2.5 <0, 12.0 >0.5 0.4 <0, 5.0 >0.5
CT 373 (48) 489 (49) 1.1 <0, 11.0 1.1 <0, 5.6
TT
  		136 (18)
 		 193 (19)
 		 4.3
 		 <0, 19.9
 		 3.3
 		 <0, 13.7
 
CC 268 (34) 313 (31) 2.7 <0, 12.2 >0.5 0.4 <0, 5.0 >0.5
CT/TT 509 (66) 682 (69) 2.4 <0, 10.6 1.7 <0, 5.6
NPAS2 rs12622050 GG 495 (64) 626 (63) 0.2 <0, 5.7 0.1 <0 <0, 2.2 0.08
AG 242 (31) 327 (33) 9.2 0.5, 27.5 5.4 0.6, 14.2
AA
  		38 (5)
 		 41 (4)
 		 21.9
 		 <0, 146.2
 		 4.0
 		 <0, 28.9
 
GG 495 (64) 626 (63) 0.2 <0, 5.7 0.04 <0 <0, 2.2 0.03
AG/AA 280 (36) 368 (37) 10.3 1.2, 28.2 5.1 0.8, 12.7
LOC728215 rs2391406 AA 309 (40) 410 (41) 8.6 0.3, 25.0 0.1 3.7 <0, 11.0 0.5
AC 368 (47) 453 (46) 1.8 <0, 9.1 0.4 <0, 3.8
CC
  		99 (13)
 		 131 (13)
 		 <0
 		 <0, 7.8
 		 0.4
 		 <0, 9.9
 
AA 309 (40) 410 (41) 8.8 0.4, 25.5 0.1 3.7 <0, 11.0 0.2
AC/CC 467 (60) 584 (59) 1.0 <0, 7.2 0.4 <0, 3.4
FLJ41481 rs4666451 CC 309 (40) 388 (39) 2.5 <0, 12.2 >0.5 1.3 <0, 6.9 >0.5
CT 358 (46) 453 (46) 1.3 <0, 10.6 1.9 <0, 6.8
TT
  		108 (14)
 		 154 (15)
 		 5.1
 		 <0, 23.6
 		 <0
 		 <0, 7.1
 
CC 309 (40) 388 (39) 2.7 <0, 12.4 >0.5 1.3 <0, 6.9 >0.5
CT/TT 466 (60) 607 (61) 2.5 <0, 10.8 1.4 <0, 5.1
LHX5 rs10850145 GG 622 (80) 800 (80) 2.9 <0, 9.9 >0.5 1.2 <0, 4.3 >0.5
AG 146 (19) 183 (18) 0.4 <0, 15.1 2.1 <0, 17.2
AA
  		9 (1)
 		 12 (1)
 		 37.3
 		 <0, 4.5e+04
 		 <0
 		 <0, 61.2
 
GG 622 (80) 800 (80) 2.8 <0, 9.9 >0.5 1.2 <0, 4.3 >0.5
AA/AG 155 (20) 195 (20) 1.3 <0, 17.2 1.2 <0, 14.3
MYCL1 rs3134615 GG 445 (58) 567 (57) 3.4 <0, 12.1 0.5 1.0 <0, 5.3 0.3
GT 276 (36) 373 (38) 3.6 <0, 16.8 2.6 <0, 8.6
TT
  		52 (7)
 		 51 (5)
 		 <0
 		 <0, 11.2
 		 <0
 		 <0, 5.8
 
GG 445 (58) 567 (57) 3.3 <0, 11.7 >0.5 1.0 <0, 5.3 >0.5
GT/TT 328 (42) 424 (43) 1.7 <0, 11.1 1.6 <0, 6.1
PARD3 rs1274466 AA 243 (31) 294 (30) 6.4 <0, 22.1 0.2 4.5 <0, 14.9 0.5
AG 378 (49) 490 (50) <0 <0, 5.8 0.5 <0, 3.8
GG
  		156 (20)
 		 205 (21)
 		 3.6
 		 <0, 17.2
 		 2.9
 		 <0, 13.3
 
AA 243 (31) 294 (30) 6.7 <0, 22.6 0.2 4.5 <0, 14.9 0.3
AG/GG 534 (69) 695 (70) 0.8 <0, 7.2 0.9 <0, 4.0
a

Entrez SNP reference ID number (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=snp)

b

The numbers of cases and controls may not sum to total due to genotyping failures.

c

Excess Odds Ratio (EOR) adjusted for year of birth and medical diagnostic radiation exposure or occupational radiation dose as appropriate. When the 95% confidence interval for the EOR excludes zero, the estimate is statistically significant. The relation of the Odds Ratio (OR) to the EOR is: OR= 1 + EOR × dose

d

Likelihood ratio test (LRT) comparing deviance of models with and without effect modification term