Table 4. Independent effect of age, vascular risk, and diagnosis on regional gray matter volume, white matter hyperintensity volume, and corpus callosum FA.

Dependent variable	Independent variable	Statistics	Subregions
GM volume			GM I	GM II	GM III	GM IV
	Diagnosis	F	9.90	3.49	0.77	20.40
		P-value	<0.001	0.032	0.465	<0.001
	Vascular Risk	F	0.14	0.21	<0.01	1.85
		P-value	0.713	0.650	0.962	0.175
	Age	F	11.04	2.06	15.95	14.72
		P-value	0.001	0.153	<0.001	<0.001
WMH volume			Frontal WMH		Posterior WMH
	Diagnosis	F	4.96		5.10
		P-value	0.007		0.007
	Vascular Risk	F	7.73		3.89
		P-value	0.006		0.049
	Age	F	40.31		69.19
		P-value	<0.001		<0.001
CC FA			CC I	CC II	CC III	CC IV
	Diagnosis	F	3.58	2.35	2.45	6.10
		P-value	0.030	0.098	0.089	0.003
	Vascular Risk	F	5.79	12.24	4.42	3.76
		P-value	0.017	0.001	0.037	0.054
	Age	F	14.03	0.05	<0.01	2.24
		P-value	<0.001	0.820	0.956	0.136

Data are F and p-values by ANCOVA including diagnosis as a factor, and age and vascular risk as covariates.

CC = corpus callosum; GM = gray matter; WMH = white matter hyperintensities FA = fractional anisotropy.