Table 1.

Genes overexpressed in mutant cells.

Gene Name	Gene Symbol	Parametric P-value	Fold Change K303R Arom 1 vs MCF-7 Arom 1
Insulin-like Growth Factor Binding Protein 3	IGFBP 3	5e-07	0.49
Insulin-like Growth Factor Binding Protein 5	IGFBP 5	5e-07	0.17
Insulin Receptor Substrate 1	IRS1	<1E-07	2,9
Insulin Receptor Substrate 2	IRS2	<1E-07	3,6
Janus Kinase 2	JAK2	<1E-07	3,7
Signal Transducer and Activator of Transcription 1	STAT1	<1E-07	15,1
v-fos FBJ murine osteosarcoma viral oncogene homolog	FOS	4e-07	5,2

Representative probesets from pathway analysis showing gene expression changes in the insulin signaling along with the p-value and the fold change of K303R-expressing cells compared to WT cells. Only genes at a fold change greater than 2 are showed. In cases where the same genes were deemed significant across multiple probesets, only one is shown.