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Model illustrating PEXEL processing and the definition of the PEXEL. (Panel A) Soluble proteins entering the P. falciparum secretory pathway undergo PEXEL cleavage (1) and N-acetylation (2) in the parasite ER lumen. (Panel B) The cleaved, N-acetylated protein is recognized by the putative translocase at the PVM (3) for export to the host RBC. The PEXEL may be defined as a novel ER peptidase cleavage site (RxL) (red) and a classical N-acetyltransferase substrate sequence (xE/Q/D) (blue).
