Table 3.

ELISA-generated Hdmx inhibition data for the derivatives of the CDLRWF lead and the control p53 peptide.

Compound	Name	% inhibition at 320 μM	IC50 (μM)a
1	p53 (17–26) b	98 ± 2	8 ± 1
4a	Boc–WF–NH2	No Inhibition	ND c
4b	Boc–WF–N(CH2)5	13 ± 1	ND c
5a	Boc–RWF–NH2	No Inhibition	ND c
5b	Boc–RWF–N(CH2)5	42 ± 3	463 ± 45
6a	Boc–LRWF–NH2	14 ± 2	ND c
6b	Boc–LRWF–N(CH2)5	82 ± 4	192 ± 27
7a	Boc–DLRWF–NH2	No Inhibition	ND c
7b	Boc–DLRWF–N(CH2)5	13 ± 1	ND c
8	c-(ADLRWF)	12 ± 1	ND c

^aCalculated from weighted non-linear fits of dose-dependent responses (see Supporting Information for details).

^bK_D of 1 has been reported to be 390 ± 20 nM (ref. ³⁴).

^cNot determined due to low activity and poor solubility at high concentrations.