Skip to main content
. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Mol Cell Endocrinol. 2010 May 6;326(1-2):3–7. doi: 10.1016/j.mce.2010.04.027

Figure 2.

Figure 2

Model for the connection between PRKAR1A mutations and acromegaly. A. The primary signaling pathways connecting hypothalamic signaling to pituitary hormone secretion are indicated for each cell type of the Pit1 lineage. See text for references. Note that Somatotrophs are primarily dependent on cAMP/PKA signaling for this process. B. Loss of PRKAR1A or activation of Gsα can cause secretion of GH independent of upstream signals.