. Author manuscript; available in PMC: 2010 Aug 17.

Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jun 11;878(23):2155–2162. doi: 10.1016/j.jchromb.2010.06.008

Table 2.

Determination of PhIP-C8-dG adducts in salmon testis DNA treated with PhIP using online column-switching LC-MS/MS SRM analysis

PhIP (mg/mL) + salmon testis DNA sample	PhIP-C8-dG adducts (per 10⁶ 2′- deoxynucleosides)^c	Intra-day CV (%)^d	Inter-day CV (%)
0.0001^a	5.5 ± 0.2	4.3	3.2
0.0010^a	49.2 ± 1.9	1.7	3.9
0.0100^b	336.2 ± 31.3	2.3	9.3
0.1000^b	2728.2 ± 133.3	4.8	4.9

10 μg of enzymatically hydrolysed DNA analysed on column

5 μg of enzymatically hydrolysed DNA analysed on column

the ± error represents the standard deviation (n = 3)

n = 3