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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Gene. 2010 Jun 21;465(1-2):9–16. doi: 10.1016/j.gene.2010.06.005

Fig. 3. Hypothetical schemes depicting the origins of HAL1 from L1 elements.

Fig. 3

(A) Internal deletion. (B) Insertion of the 3’-end sequence of another L1 element. (C) Insertion of an 5’-inverted L1 element due to twin priming (Ostertag and Kazazian, 2001). (D) Template switching during reverse transcription. Bold lines indicate DNA strands. The wavy lines indicate RNA transcripts. Regions from different L1 molecules (RNA or DNA) are differentiated by yellow and blue colors. Blue solid ovals indicate the transcription stop site of the L1 or HAL1 elements. Arrows above the upper DNA strand indicate the transcription start site. The transcript of the newly formed HAL1 element is shown below (in black).