TABLE 3.

Group differences in predicting high hsCRP risk and inflammation factor levels. Model 1 shows the unadjusted analysis. Model 2 shows the analysis adjusted for sex and use of anti-inflammatory medications. Model 3 indexes the “depression-history hypothesis”. Model 4 indexes the “childhood-risk hypothesis”. Model 5 indexes the “adulthood-risk hypothesis”. Model 6 indexes the “health-risk hypothesis”. Model 7 indexes the “health-behavior hypothesis”.

	Controls (N=673)	Depressed-only (N=109)	Maltreated-only (N=56)	Depressed+ Maltreated (N=27)
C-Reactive Protein >3 mg/L †
1. Unadjusted	-	1.40 [0.97;2.01]	1.69 [1.10;2.60]	2.07 [1.23;3.47]
2. Sex, medications	-	1.34 [0.93;1.92]	1.61 [1.03;2.50]	2.06 [1.21;3.51]
3. Depression recurrence*	-	1.52 [1.00;2.34]	1.62 [1.04;2.53]	2.41 [1.31;4.43]
4. SES in Childhood*	-	1.31 [0.91;1.87]	1.52 [0.98;2.35]	1.92 [1.12;3.29]
5. SES in Adulthood*	-	1.30 [0.90;1.87]	1.57 [1.01;2.44]	1.97 [1.16;3.37]
6. CV Risk Cluster*	-	1.32 [0.93;1.87]	1.56 [1.02;2.38]	2.00 [1.21;3.32]
7. Smoking*	-	1.35 [0.94;1.94]	1.64 [1.05;2.55]	2.13 [1.24;3.66]
Inflammation Factor §
1. Unadjusted	-	0.12 [−0.08;0.33]	0.31 [0.04;0.58]	0.53 [0.15;0.91]
2. Sex, medications	-	0.10 [−0.10;0.30]	0.27 [0.00;0.55]	0.52 [0.14;0.90]
3. Depression recurrence*	-	0.10 [−0.13;0.33]	0.27 [0.00;0.55]	0.52 [0.12;0.92]
4. SES in Childhood*	-	0.09 [−0.11;0.29]	0.22 [−0.05;0.49]	0.47 [0.10;0.85]
5. SES in Adulthood*	-	0.07 [−0.13;0.27]	0.26 [−0.02;0.53]	0.49 [0.11;0.86]
6. CV Risk Cluster*	-	0.10 [−0.09;0.29]	0.25 [0.00;0.51]	0.50 [0.14;0.85]
7. Smoking*	-	0.09 [−0.11;0.29]	0.21 [−0.06;0.48]	0.42 [0.04;0.80]

^†Cox regression analysis with constant time of follow-up and robust variance. Controls (i.e., non-depressed non-maltreated individuals) were considered the reference group.

^§Ordinary-least-squares regression analysis. Controls were considered the reference group.

^*Adjusted analyses also include sex and medications covariates.