Table 3.
Association between nevus phenotype and nevus genotype and risk of melanoma
| Risk factor | Control | Case | Univariate OR (95% CI) |
Multivariable OR1 (95% CI)* |
Adjusted OR2 (95% CI)ˆ |
|---|---|---|---|---|---|
| Residual log body nevus number quartile | |||||
| Q1 | 126 (25) | 55 (6) | - | - | - |
| Q2 | 126 (25) | 127 (14) | 2.31 (1.55, 3.45) | 1.98 (1.29, 3.03) | 2.64 (1.71, 4.08) |
| Q3 | 126 (25) | 205 (22) | 3.73 (2.53, 5.49) | 3.12 (2.07, 4.70) | 4.32 (2.84, 6.59) |
| Q4 | 126 (25) | 551 (59) | 10.02 (6.91, 14.52) | 7.47 (5.01, 11.14) | 11.66 (7.78, 17.48) |
| Atypical nevi | |||||
| 0 | 462 (92) | 657 (70) | - | - | - |
| 1+ | 42 (8) | 281 (30) | 4.70 (3.33, 6.64) | 2.80 (1.91, 4.10) | 3.95 (2.75, 5.66) |
| rs12203592_chr6 | |||||
| CC | 279 (57) | 598 (65) | - | - | - |
| CT | 185 (38) | 279 (30) | 0.70 (0.56, 0.89) | 0.66 (0.51, 0.86) | 0.67 (0.52, 0.87) |
| TT | 22 (5) | 42 (5) | 0.89 (0.52, 1.52) | 1.04 (0.57, 1.91) | 0.80 (0.44, 1.44) |
| Linear trend | 0.80 (0.66, 0.96) | 0.83 (0.67, 1.03) | 0.76 (0.61, 0.94) | ||
| rs7023329_chr9 | |||||
| GG | 94 (20) | 250 (29) | - | - | - |
| GA | 274 (58) | 441 (50) | 0.61 (0.46, 0.80) | 0.65 (0.48, 0.88) | 0.58 (0.43, 0.77) |
| AA | 107 (23) | 184 (21) | 0.65 (0.46, 0.90) | 0.70 (0.48, 1.01) | 0.63 (0.45, 0.90) |
| Linear trend | 0.80 (0.68, 0.95) | 0.85 (0.70, 1.02) | 0.79 (0.67, 0.94) | ||
| rs2284063_chr22 | |||||
| GG | 193 (40) | 421 (47 | - | - | - |
| GA | 226 (47) | 396 (44) | 0.80 (0.63, 1.02) | 0.86 (0.66, 1.13) | 0.82 (0.64, 1.06) |
| AA | 66 (14) | 87 (10) | 0.60 (0.42, 0.87) | 0.72 (0.48, 1.09) | 0.61 (0.42, 0.89) |
| Linear trend | 0.79 (0.67, 0.93) | 0.86 (0.71, 1.04) | 0.79 (0.67, 0.94) | ||
| Total number of variants (T allele for rs12203592_chr6, and A allele for rs7023329_chr9 and rs2284063_chr22) | |||||
| 0/1 | 122 (26) | 303 (35) | - | - | - |
| 2 | 154 (33) | 306 (36) | 0.80 (0.60, 1.07) | 0.81 (0.59, 1.11) | 0.75 (0.56, 1.02) |
| 3 | 133 (29) | 186 (22) | 0.56 (0.42, 0.77) | 0.67 (0.48, 0.95) | 0.55 (0.40, 0.76) |
| 4+ | 57 (12) | 60 (7) | 0.42 (0.28, 0.64) | 0.58 (0.36, 0.92) | 0.43 (0.28, 0.67) |
| Linear trend | 0.77 (0.69, 0.86) | 0.85 (0.75, 0.95) | 0.77 (0.69, 0.86) | ||
*
All risk factors listed in the table except for total number of variants were included in the multivariable model (multivariable OR1); age-sex corrected log body nevus number and presence of atypical nevi were adjusted in OR1 for total number of variants;
ˆ
adjusted for age, sex, hair color, freckling as child, general skin type without other nevus phenotype or genotype.