Figure 3.

Neurons in the ischemic core of the cPLA₂α^-/- mouse are protected from injury. A: Neuronal swelling was measured by threshold densitometry in brains from cPLA₂α^+/+ and cPLA₂α^-/- mice after 2-hour MCAO, 2-hour MCAO and 2 hours of reperfusion, or sham surgery; n = 3 mice/condition; * P < 0.01, unpaired t-test comparing cPLA₂α^+/+ to -/- at same condition. B: Nissl staining of cPLA₂α^+/+ and cPLA₂α^-/- brains after 2-hour MCAO and 6 hours of reperfusion. Vacuolated neurons (arrows) and nuclear condensation (arrowheads) are seen in the ischemic core of cPLA₂α^+/+ mice. Ipsi, ipsilateral; Contra, contralateral; C, ischemic core; P, penumbra.