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. 2010 Aug 17;5(8):e12220. doi: 10.1371/journal.pone.0012220

Figure 2. Mast cells do not affect the severity of colitis triggered by piroxicam.

Figure 2

Mice of the indicated genotypes ± reconstitution with WT or Il10 −/− BMMC received 200 ppm piroxicam ×7 days to trigger the onset of colitis. Tissue was harvested for histologic analysis 16 d later. WT or sash mice ± reconstitution with WT BMMC did not develop colitis in this study. Mice deficient in IL-10 uniformly developed colitis, however the presence or absence of mast cells and whether or not the mast cells could produce IL-10 did not affect the severity of inflammation.