Figure 5. Mast cells do not affect long-term colitis severity in Helicobacter-infected Il10 ^−/− mice.

Il10 ^−/− mice with (n = 21) and without (n = 24) genetic deficiency of mast cells were infected with H. rodentium and H. typhlonius and monitored for up to 27 wks. DKO mice had a small increase in histologic score compared with mice deficient in IL-10 alone (A; p = 0.03), but there was no difference in survival between DKO and mast cell-sufficient Il10 ^−/− mice (B).