Figure 8. Permeability of the intestinal barrier in IL-10^−/− and DKO mice.

Mice of the indicated ages and genotypes were gavaged with phenol red and the amount of dye absorbed was determined by spectrophotometric measurement of urine. Each point shown represents the average of 2–4 mice tested in a single experiment. Mast cell-deficient DKO and sash mice had significantly increased dye recovery compared with Il10 ^−/− mice (p = 0.02 for differences in data point elevation via linear regression analysis). The total numbers of mice tested were: Il10 ^−/− (n = 14), DKO (n = 18), and sash (n = 22).