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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Dev Neurobiol. 2010 Apr;70(5):304–322. doi: 10.1002/dneu.20765

Figure 2. BDNF-TrkB signaling Regulates Multiple Events through PLCγ, PI3K and MAPK pathways.

Figure 2

(a) PI3K pathway regulates trafficking and PSD-95 to a synapse and cAMP regulates formation of synaptic PSD-95-TrkB complex.

(b) BDNF-TrkB signaling activates MAPK/Erk, increasese cAMP and activate CREB-regulated gene transcription.

(c) BDNF-TrkB signaling regulates protein translation through both MAPK/Erk and PI3K-Akt-mTOR pathways. PI3K-Akt also regulates protein trafficking in ER and Golgi.

(d) A diagram showing BDNF-TrkB signaling regulates multiple molecular events through three pathways in parallel.