Table 2.
Details of synonymous and non-synonymous substitutions at drug resistance positions among the partially concordant and discordant mutations.
| Category | Gene | Codon | Amino acid/bases detected by both assays | |||
|---|---|---|---|---|---|---|
| ViroSeq™ | In-house | |||||
| Amino acid | Base | Amino acid | Base | |||
| Partial concordance | PR | 10 | LE | YTT | L | CTT |
| 33 | F | TTY | F | TTT | ||
| 48 | G | GGR | G | GGG | ||
| 63 | PL | CYT | L | CTT | ||
| 63 | PA | SCT | A | GCT | ||
| 63 | P/L/A/S/ | SYC | A | GYC | ||
| 71 | A | GCW | A | GCA | ||
| 71 | IV | RTT | V | GTT | ||
| RT | 44 | ML | WTG | L | TTG | |
| 69 | IT | AYT | T | ACT | ||
| 74 | IL | WTA | I | ATA | ||
| 75 | TA | RCA | T | ACA | ||
| 98 | AG | GSA | G | GGA | ||
| 98 | AG | GSA | G | GGA | ||
| 101 | KE | RAA | K | AAA | ||
| 101 | E | GAA | EQ | SAA | ||
| 103 | N | AAC | KN | AAM | ||
| 106 | V | GTR | V | GTA | ||
| 118 | IV | RTT | V | GTT | ||
| 190 | AG | GSA | G | GGA | ||
| 190 | A | GCA | A | GCR | ||
| 190 | G | GGA | AG | GSA | ||
| 210 | L | TTA | LV | STG | ||
| Discordance | RT | 74 | VL | KTA | IL | RTA |
| 75 | V | GTA | I | ATA | ||