Table 1.
Demographic, clinical, and EEG/MRI characteristics of enrolled patients (N=267; patients with normal EEGs not included). Left side of the table includes comparisons between all patients with JME vs. other IGEs, right side of the table compares seizure-free vs. not seizure-free patients with JME or other IGEs (GTC – generalized tonic-clonic seizure; GSWD – generalized spike and wave discharge; ED – epileptiform discharge)
| Not JME | JME | p-value | Not JME | JME | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Seizure-free | Not seizure free | p-value | Seizure free | Not seizure free | p-value | ||||||||||
| Age of onset | 17.16 | 11.30 | 13.70 | 5.51 | 0.001 | 17.80 | 11.85 | 14.24 | 7.90 | 0.125 | 13.98 | 5.62 | 12.13 | 4.70 | 0.216 |
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| male | 53 | 32.9 | 39 | 36.8 | 43 | 32.6 | 10 | 34.5 | 35 | 38.9 | 4 | 25.0 | |||
| 0.514 | 0.831 | 0.402 | |||||||||||||
| female | 108 | 67.1 | 67 | 63.2 | 89 | 67.4 | 19 | 65.5 | 55 | 61.1 | 12 | 75.0 | |||
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| GTC | 149 | 92.5 | 98 | 92.5 | 1.000 | 120 | 90.9 | 29 | 100.0 | 0.126 | 82 | 91.1 | 16 | 100.0 | 0.604 |
| Absence seizures | 97 | 60.2 | 51 | 48.1 | 0.059 | 75 | 56.8 | 22 | 75.9 | 0.063 | 37 | 41.1 | 14 | 87.5 | 0.001 |
| Family history of epilepsy (any type) |
72 | 44.7 | 54 | 50.9 | 0.119 | 59 | 44.7 | 13 | 44.8 | 0.990 | 43 | 47.8 | 11 | 68.8 | 0.281 |
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| GSWD on most recent EEG | 92 | 57.1 | 74 | 69.8 | 0.040 | 70 | 53.0 | 22 | 75.9 | 0.037 | 59 | 65.6 | 15 | 93.8 | 0.035 |
| Other abnormalities on most recent EEG |
30 | 18.6 | 13 | 12.3 | 0.178 | 20 | 15.2 | 10 | 34.5 | 0.032 | 7 | 7.8 | 6 | 37.5 | 0.004 |
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| GSWD on the first EEG | 50 | 78.1 | 33 | 80.5 | 0.811 | 46 | 80.7 | 4 | 57.1 | 0.171 | 32 | 80.0 | 1 | 100.0 | 1.000 |
| Other abnormalities on the first EEG |
10 | 15.4 | 5 | 12.2 | 0.778 | 6 | 10.3 | 4 | 57.1 | 0.008 | 5 | 12.5 | 0 | 0 | 1.000 |
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| Any EEG - other abnormalities |
72 | 44.7 | 35 | 33.0 | 0.074 | 49 | 37.1 | 23 | 79.3 | 0.000 | 24 | 26.7 | 11 | 68.8 | 0.003 |
| Any EEG - focal slowing | 29 | 18.0 | 15 | 14.2 | 0.501 | 19 | 14.4 | 10 | 34.5 | 0.016 | 8 | 8.9 | 7 | 43.8 | 0.002 |
| Any EEG - focal EDs | 47 | 29.2 | 28 | 26.4 | 0.677 | 31 | 23.5 | 16 | 55.2 | 0.001 | 19 | 21.1 | 9 | 56.3 | 0.011 |
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| MRI NORMAL | 142 | 88.2 | 93 | 87.7 | 0.931 | 116 | 87.9 | 26 | 89.7 | 0.850 | 78 | 86.7 | 15 | 93.8 | 0.563 |
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| Reviewed - last EEG | 129 | 80.1 | 75 | 70.8 | 0.105 | 106 | 80.3 | 23 | 79.3 | 1.000 | 62 | 68.9 | 13 | 81.3 | 0.386 |
| Reviewed - GSWD present | 69 | 53.5 | 47 | 62.7 | 0.241 | 52 | 49.1 | 17 | 73.9 | 0.038 | 35 | 56.5 | 12 | 92.3 | 0.024 |
| Reviewed - asymmetric EDs | 32 | 24.8 | 18 | 24.0 | 1.000 | 18 | 17.0 | 14 | 60.9 | 0.000 | 11 | 17.7 | 7 | 53.8 | 0.011 |
| Reviewed - other focal abnormalities |
14 | 10.9 | 7 | 9.3 | 0.815 | 8 | 7.5 | 6 | 26.1 | 0.019 | 4 | 6.5 | 3 | 23.1 | 0.095 |
| Reviewed - normal last EEG | 55 | 42.6 | 24 | 32.0 | 0.140 | 50 | 47.2 | 5 | 21.7 | 0.035 | 23 | 37.1 | 1 | 7.7 | 0.050 |
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