Table 3.
Total costs, number of life-years gained, and number of cases of colorectal cancer (CRC) per 1000 65-year-olds by screening strategy*
| Strategy | MISCAN | SimCRC | CRC-SPIN | |||||||||
| Total costs, million $ | LYG | No. of CRC cases | Reduction in cases, % | Total costs, million $ | LYG | No. of CRC cases | Reduction in cases, % | Total costs, million $ | LYG | No. of CRC cases | Reduction in cases, % | |
| No screening | 4.03 | 0 | 57 | — | 3.54 | 0 | 60 | — | 3.00 | 0 | 53 | — |
| HII yearly | 3.70 | 116.5 | 39 | 32 | 2.80 | 113.9 | 36 | 41 | 2.17 | 114.5 | 29 | 46 |
| HS yearly | 3.75 | 142.8 | 32 | 44 | 2.65 | 150.7 | 26 | 58 | 1.99 | 155.1 | 18 | 67 |
| IFOBT yearly | 3.82 | 141.0 | 33 | 42 | 2.75 | 148.3 | 27 | 55 | 2.11 | 150.4 | 20 | 63 |
| SIGB 5 yearly | 3.81 | 132.2 | 30 | 47 | 2.85 | 120.6 | 29 | 52 | 2.29 | 133.7 | 21 | 60 |
| SIG 5 yearly | 3.80 | 135.4 | 30 | 48 | 2.81 | 128.0 | 27 | 56 | 2.16 | 142.2 | 18 | 65 |
| HII yearly + SIGB 5 yearly | 3.67 | 149.1 | 29 | 50 | 2.64 | 157.7 | 23 | 63 | 2.15 | 163.7 | 15 | 72 |
| HII yearly + SIG 5 yearly | 3.86 | 149.9 | 28 | 51 | 2.62 | 160.1 | 22 | 64 | 2.06 | 166.7 | 14 | 74 |
| HS yearly + SIGB 5 yearly | 3.75 | 154.1 | 27 | 52 | 2.69 | 169.3 | 19 | 68 | 2.12 | 175.9 | 11 | 78 |
| HS yearly + SIG 5 yearly | 3.93 | 154.1 | 27 | 53 | 2.69 | 170.2 | 19 | 69 | 2.05 | 176.8 | 11 | 79 |
| IFOBT yearly + SIGB 5 yearly | 4.03 | 154.3 | 27 | 52 | 2.81 | 168.9 | 20 | 67 | 2.24 | 174.4 | 12 | 77 |
| IFOBT yearly + SIG 5 yearly | 4.00 | 154.3 | 27 | 52 | 2.80 | 169.9 | 19 | 68 | 2.16 | 175.8 | 11 | 78 |
| COL 10 yearly | 3.84 | 151.6 | 27 | 53 | 2.68 | 171.3 | 17 | 72 | 1.98 | 184.9 | 8 | 85 |
| CT colonography DoD 5 yearly† | 4.54 | 149.5 | 28 | 51 | 3.28 | 168.2 | 18 | 71 | 2.65 | 177.7 | 10 | 81 |
| CT colonography NCTC 5 yearly† | 4.59 | 142.7 | 30 | 48 | 3.35 | 160.2 | 20 | 67 | 2.70 | 172.2 | 11 | 78 |
*
— = not applicable; COL = colonoscopy; CRC-SPIN = Colorectal Cancer Simulated Population model for Incidence and Natural History; CT = computed tomographic; DoD = Department of Defense study parameters; HII = Hemoccult II; HS = Hemoccult SENSA; IFOBT = immunochemical fecal occult blood test; LYG = life-years gained compared with no screening; MISCAN = Microsimulation Screening Analysis model; NCTC = National CT Colonography Trial parameters; SIG = sigmoidoscopy without biopsy; SIGB = sigmoidoscopy with biopsy; SimCRC = Simulation Model of Colorectal Cancer.
† Six-millimeter threshold for colonoscopy referral.