TABLE 3.
Mutant viruses containing the HPV16 L2 C-terminus and the HPV18 L1 N-terminus.
| VIRUS | Independently immortalized lines (line/attemptsa) | Infectious virus producing lines (lines producing/total linesb) | TITERS | Independent Measurementsc | Titer Range | Ave/sdd |
|---|---|---|---|---|---|---|
| HPV18-L2(16)L1(18/16) | 4/4 | 0/4 | <20 | 4 | 0 | 0/0 |
| HPV18-L2(18/16)L1(18) | 5/5 | 1/5 | 100 | 5 | 0–100 | 20/44.7 |
| HPV18-L2(16)L1(18) | 20/20 | 1/20 | 20 | 20 | 0–20 | 1/4.5 |
a
The number of established continuous immortalized cell lines created with the particular HPV chimera over the number of attempts to derive such a cell line.
b
The number of cell lines able to produce measurable infectious virus over the number of establishe20/44.7d cell lines.
c
Number of independent measurements made for each HPV construct.
d
Titer average/standard deviation