Figure 3. MPA rescues growth of BT-474 xenograft tumors in ovariectomized mice.
(A) As in Figure 2A, except MPA pellets were implanted in ovariectomized mice 8 days after (MPA-L, red arrow) or 48 h before (MPA-E, green arrow) inoculation with tumor cells. Control animals (blue line) were co-injected with estrogen- and placebo-containing pellets. (B) Average body weight was calculated for each treatment group at the indicated time points. *p <0.05, significantly different from E2 only group ANOVA (Student-Newman-Keuls test).