Table 4.

The effect of dose and CYP2D6 phenotype on the imipramine to desipramine AUC_m/AUC_p ratio after PO administration of imipramine.

Imipramine Dose (mg)	CYP2D6 Phenotype	Imipramine AUC (nmol*h/mL)	Desipramine AUC (nmol*h/mL)	Observed AUCm/AUCp	References
25	EM	0.68	0.37	0.54	1, 2, 3
25	PM	1.2	3.4	2.9
50	EM	1.4	0.79	0.58
100	EM	3.1	1.6	0.50

Notes: All AUC values were determined after single dose administration. Reference numbers coincide with the below provided references and not with the bibliography references.

References: 1Albers et al, 2000; 2Koyama et al, 1994 and 3Kurtz et al, 1997.