. Author manuscript; available in PMC: 2011 Sep 1.

Published in final edited form as: J Hepatol. 2010 May 31;53(3):551–557. doi: 10.1016/j.jhep.2010.03.029

Table 3. Serum methionine metabolites and vitamin levels.

HCY: homocysteine; SAH: S-adenosylhomocysteine; SAM: S-adenosylmethionine; CYSTAT: cystathionine; ABU: α-aminobutyrate; DMG: dimethylglycine.

	Alcoholic Liver Disease (ALD) (n = 40)	Active drinkers w/o liver disease (AD) (n = 26)	Healthy Subjects (HS) (n = 28)	Overall p value
HCY μmol/L	10.2 (5.4-58.3)^a	8.8 (5.8-23)^a	6.4 (4.1-10)^b	<.001
SAH nmol/L	33 (15-142)^a	26 (13-74)^{a, b}	20 (14-64)^b	<.02
SAM nmol/L	120 (63-328)^a	96 (49-341)^b	88.5 (72-160)^b	<.02
SAM/SAH	4.2 (0.4-9.2)	4 (1.2-10.3)	4.1 (1.2-7)	0.9
Methionine μmol/L	30 (11.4-77.2)^a	24 (10.7-45.8)^b	25.1 (17-35.4)^b	<.02
CYSTAT nmol/L	300 (88-1786)^a	111 (72-944)^b	135 (86-538)^b	<.001
Cysteine μmol/L	352 (231-528)^a	318 (259-404)^{a, b}	319 (255-383)^b	<.05
ABU μmol/L	11.3 (3.9-38.2)^a	20.4 (6.1-67.8)^b	16.1 (7.4-31.8)^b	<.05
ABU/CYSTAT	0.03 (0.005-0.22)^a	0.13 (0.01-0.5)^b	0.1 (0.02-0.2)^b	<.001
DMG μmol/L	4.2 (2.3-89.4)^a	3.5 (1.7-5.6)^b	3.1 (1.7-7.6)^b	<.001
Serine μmol/L	100 (51-168)	94 (59-119)	96.5 (64-134)	0.43
Glycine μmol/L	200 (120-341)	202 (115-305)	200 (158-314)	0.73