Spread of virus from epithelial cells to neuron cell bodies in Campenot chambers. A and B. HaCaT cells were seeded in the N chamber and allowed to polarize for 1 week prior to infection with 1 × 105 PFU of WT, gE2-del, or rgE2-del virus. At 48 hpi, contents of the S (A) and N (B) chamber were harvested and titered on Vero cells. C. Neurites in the N chamber were infected with 1 × 105 PFU of WT, gE2-del, or rgE2-del virus in the absence of HaCaT cells. At 24 hpi, contents of the S chamber were harvested and titered on Vero cells. n=5 chambers for each assay ± SEM.