TABLE 2.
Commonly Modulated Blood Cytokines Associated with Pathological Responses
| Pathological responsea,b | Cytokinesc |
| Acute-phase response | IL1β, IL6, TNF-α |
| Cytokine storm/release | IL2, IL6, IL8, IL10, IFNγ, TNF-α |
| Fibrosis | TGFβ |
| Hemophagocytic syndrome | IFNγ, IL1β, IL6, TNF-α |
| Neutrophilic inflammation | IL8, MIP-1, TNF-α |
| Systemic inflammatory response syndrome | IL6, MCP-1, TNF-α |
| Th1 immune response | IFNγ, IL2, IL12 |
| Th2 immune response | IL4, IL5, IL6, IL10, IL13 |
a
Pathological responses observed in toxicity studies, includes inflammation, immunity, and repair.
b
Descriptions of immunostimulatory toxic responses are in Gribble et al. (2007).
c
Cytokines that drive the response and are most commonly at detectable systemic levels.