FIG. 2.

Hormonal suppression improved spermatogenic recovery from both endogenous and donor-derived stem spermatogonia in irradiated mouse testis in Exp. 1 (A) and Exp. 2 (B). The TDI is the percentage of tubule cross sections with more than three differentiated germ cells. “Endogenous” indicates the differentiated germ cells that were derived from surviving stem spermatogonia of the recipient. “Donor” indicates the differentiated germ cells that were derived from GFP-positive transplanted stem spermatogonia. The statistical analyses of 12- and 13.5-Gy donor TDI data in panel (B) were conducted by a nonparametric method because the data are not normally distributed. N = 3–4 (panel A) and N = 4–18 (panel B). “a” and “b”, p < 0.05 versus the sham- or 4-week–treated groups, respectively.