FIG. 4.

Time course of accessory sexual organ or spermatogenic recovery in mice irradiated with 10.5 Gy (A–E) from Exp. 3 or 13.5 Gy (F–J) from Exp. 4, as measured by SV weight (A and F), epididymal weight (B and G), testis weight (C and H), testicular sperm head count (note log scale) (D and I), and cauda epididymal sperm count (E and J). Groups are designated as Sham, Hormone (GnRH-ant + flutamide only, no transplantation), Transplant (transplantation only), Hormone + Transplant (GnRH + flutamide and spermatogonial transplantation). N = 10 for 46-week time point data and 5 for all other time points for both irradiation doses. “a,” “b,” and “c”, p < 0.05 versus values in the sham group, hormone group, and transplant group, respectively. Ellipses in (K) identify those mice that were fertile.