FIG. 6.

Time course of fertility recovery expressed as probability of having returned to fertility for male mice irradiated with 10.5 Gy with or without hormone suppression (A) or irradiated with 13.5 Gy with or without hormone suppression or spermatogonial transplantation (B) by Kaplan-Meier survival analysis. Relative fecundity (fraction of males that were fertile × litters per fertile male per 5-week time period × average litter size) for male mice irradiated with 10.5 Gy, with or without hormone suppression (C), or irradiated with 13.5 Gy, with or without hormone suppression or spermatogonial transplantation (D). Note, for comparison, that the calculated Relative fecundity for our unirradiated, non-hormonally treated control mice was 21.4. Symbols in panels (A and B) represent times at which individual mouse became fertile or were censored (i.e., the time of euthanasia before they became fertile). *p < 0.05 compared with values of sham-treated group. #p < 0.05 compared with values of sham, hormonal suppression, or transplant groups.