TABLE 1.

Effects of Hormone Suppression on Weights and Testosterone Levels

Experiment and irradiation dose	Hormonal suppression	Analysis time (weeks after irradiation)	Body weight (g)	Testis weight (mg)	SV weight (mg)	Serum testosterone concentration (ng/ml)
Exp. 1
10.5 Gy	Sham	11	29 ± 1a	25 ± 1a	300 ± 12a	2.8 ± 0.8a
11.5 Gy	4 weeks GnRH-ant	11	27 ± 1a	24 ± 1a	260 ± 7b	3.2 ± 0.9a
12.5 Gy	11 weeks GnRH-ant	11	25 ± 1b	14 ± 1b	22 ± 2c	0.5 ± 0.1b
Exp. 2	Sham	11	28 ± 0d	29 ± 1d	256 ± 12d	1.2 ± 0.3d
12 Gy	4 weeks GnRH-ant + flutamide	4	25 ± 0e	14 ± 0e	21 ± 3e	2 ± 0.9d
13.5 Gy	4 weeks GnRH-ant + flutamide	11	27 ± 0d	27 ± 1d	241 ± 7d	0.9 ± 0.2d
	11 weeks GnRH-ant + flutamide	11	25 ± 0e	11 ± 0f	10 ± 1e	0.1 ± 0.0e

Note. The data of three irradiation doses from Exp. 1 were pooled because ANOVA analysis showed no significant difference among them. The data from the two irradiation doses from Exp. 2 were pooled because t-test analysis showed no significant difference between them except for the SV weights of 11-week treatments (9 ± 0 mg at 12 Gy vs. 13 ± 2 mg at 13.5 Gy), both of which were dramatically lower than those in control mice. N was between 9 and 29 for weights and between 5 and 12 for serum testosterone concentrations. For a given parameter, values that are significantly different from each other (p < 0.05) within each experiment are indicated by different letters.