Table 2.
Normalized Urinary Melatonin and Risk of Incident Hypertension
| Quartiles of aMT6s/creatinine ratio, ng/mg | |||||
|---|---|---|---|---|---|
| 5.5 (<10.1) |
13.8 (10.1-16.9) |
21.0 (17.0-27.0) |
36.9 (>27.0) |
p-trend | |
| No. of participants | 138 | 139 | 139 | 138 | |
| No. of cases | 49 | 33 | 22 | 21 | |
| Age-adjusted RR (95% CI) | 1.0 (ref) | 0.63 (0.40-0.98) | 0.42 (0.25-0.70) | 0.38 (0.23-0.65) | <0.001 |
| Multivariable RR (95% CI) | 1.0 (ref) | 0.66 (0.42-1.05) | 0.42 (0.25-0.72) | 0.49 (0.28-0.85) | <0.001 |
Multivariable models adjusted for age, BMI, (BMI)2, physical activity, alcohol intake, smoking, status, urine creatinine, and family history of hypertension.