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. Author manuscript; available in PMC: 2010 Aug 18.
Published in final edited form as: Neuroscience. 2004;126(3):533–540. doi: 10.1016/j.neuroscience.2004.03.036

Fig. 4.

Fig. 4

Binding of endogenous CRH to the CRF1- receptor is required for stress-evoked transcriptional activation of receptor-bearing neurons. (A, D) Little pCREB is found in a stress-free hippocampus. (B, E) Immediately after stress, pCREB is abundant in CRF1 immunoreactive neurons. (C, F) Pre-administration of the selective CRF1 blocker R121919 attenuates stress-evoked pCREB. This ‘dampening’ of CREB phosphorylation is particularly prominent in CRF1 expressing pyramidal neurons. Scale bars = 360 µm (A–C) and 60 µm (D–F).