Table 3.
Naltrexone dose | ||||||
---|---|---|---|---|---|---|
Variable | MJ strength | 0 mg | 12 mg | 25 mg | 50 mg | 100 mg |
DAT: average speed (cm/s) | Inactive | 7.3 (0.2) | 6.6 (0.2)* | 6.9 (0.2)* | 6.7 (0.2)* | 7.0 (0.2)* |
Active | 7.0 (0.2) | 7.0 (0.2) | 7.1 (0.2) | 6.9 (0.2) | 6.9 (0.2) | |
DSST:Total attempts | Inactive | 86.2 (1.8) | 86.7 (1.7) | 83.4 (1.7) | 83.6 (1.8) | 82.1 (1.6)* |
Active | 86.1 (1.7) | 84.7 (1.6) | 83.5 (1.6) | 82.1 (1.4)* | 83.0 (1.7)* | |
DRT: delayed recognition (% correct) | Inactive | 66.7 (5.1) | 57.5 (5.3) | 49.4 (5.4)* | 60.9 (5.3) | 63.2 (5.2) |
Active | 66.7 (5.1) | 57.5 (5.3) | 57.5 (5.3) | 59.8 (5.3)* | 66.7 (5.1) |
Data are presented as average values (±SEM) across post-smoking time points (30, 75, and 180 min after smoking). Significant differences between active and placebo naltrexone are indicated (*p≤0.01)