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. 2010 Aug 18;5(8):e12233. doi: 10.1371/journal.pone.0012233

Table 1. Voxel-based studies included in the meta-analysis.

Voxel-based Studies Disorder Type Mean Global tissue Sample Size Mean Age
IQ Difference Subjects Controls Subjects Controls
Autism Spectrum Disorders
Abell et al., 1999 Asperger >70 n/a 15 15 28.8 25
Boddaert et al., 2004 Autism <70 n/a 21 12 9.3 10.8
Bonilha et al., 2008 Autism <70 n/a 12 16 12.4 13.2
Brieber et al., 2007 HFA, Asperger >70 No 15 15 14.2 13.3
Craig et al., 2007 HFA, Asperger >70 No 14 19 37.9 35
Ecker et al., 2009 HFA >70 No 22 22 27 28
Hyde et al., 2009 HFA >70 No 15 13 22.7 19.2
Ke et al., 2008 HFA >70 No 17 15 10 9.7
Kwon et al., 2004 HFA, Asperger >70 n/a 20 13 14 13.6
McAlonan et al., 2002 Asperger >70 No 21 24 32 33
McAlonan et al., 2008 HFA, Asperger >70 No 33 55 11.4 10.7
Roja et al., 2006 HFA >70 No 24 23 22.6 21.4
Toal et al., 2009 Autism, HFA >70 No 65 33 31 32
Waiter et al., 2004 HFA, Asperger >70 >GM 16 16 15.4 15.5
Wilson et al., 2009 HFA >70 No 10 10 30 29.4
320 301 21.2 20.7
Schizophrenia
Chua et al., 2007 NN-FES >70 <GM 26 38 32 33
Ebdrup et al. 2010 NN-FES >70 No 29 43 25.7 26.9
Kasparek et al., 2007 NT-FES (7 weeks) n/a No 49 127 23.7 24.1
Lui et al., 2009 NN-FES >70 n/a 68 68 24.7 24.7
Meda et al., 2008 (WPIC) NN-FES n/a No 22 21 25 26.2
Molina et al. 2010 NT-FES (<1 week) >70 No 30 40 25.8 29.4
Salgado-Pineda et al., 2003 NN-FES n/a No 13 13 23.8 23.4
Schaufelberger et al., 2007 NT-FES (<18 weeks) >70 No 62 94 27.6 30.2
Venkatasubramanian, 2010 NN-FES >70 <GM 30 27 30.1 27.4
Witthaus et al, 2009 NT-FES (<2 weeks) >70 No 23 29 26.4 25.7
352 500 26.5 27.1

Global tissue difference is any significant total grey matter difference compared to controls (HFA, high-functioning autism; NN-FES, neuroleptic-naïve first episode schizophrenia patients; NT-FES, neuroleptic-treated first episode schizophrenia patients; GM grey, matter).