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. 2010 Aug 18;5(8):e12262. doi: 10.1371/journal.pone.0012262

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Berretta, Moscato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The joint expression of the probe for PKP1 (Plakophilin 1 - ectodermal dysplasia/skin fragility syndrome - NM_000299) and the probe for JUP (Junction plakoglobin - BX648177), as added values on the x-axis, against the expression of the probe for DSP (Desmoplakin - NM_004415 Hs.519873) on the y-axis. There is a clear common downregulation trend of these biomarkers from the normal skin (Skin) to the nevi (MN) and to the primay melanoma and metastic melanoma samples (PM and MM respectively).