Figure 10. Expression of a probe for CLDN1 (Claudin 1) (y-axis) as a function of a probe for Aquaporin 3 (x-axis).

Other members of the aquaporin family of proteins have a similar behaviour. AQP3, together with CLDN1 are key components of the tight junction complexes of the epidermis and their joint loss of expression seem to be related to a transition to a more malignant phenotype. We use the same color coding as Figure 9.