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. Author manuscript; available in PMC: 2011 Aug 25.
Published in final edited form as: J Am Chem Soc. 2010 Aug 25;132(33):11443–11445. doi: 10.1021/ja105108q

Figure 2.

Figure 2

Conserved overall fold of the ICIβ2AR-t4l, 2β2AR-t4l and Alpβ2AR-t4l structures compared to Timβ2AR-t4l and Carβ2AR-t4l. (a) Superimposition of all β2AR-t4l crystal structures determined to date (t4l omitted); ICIβ2AR-t4l (yellow), 2β2AR-t4l (green), Alpβ2AR-t4l (blue), Timβ2AR-t4l (magenta) and Carβ2AR-t4l (grey) (b) Close view of the ligand binding site showing the conserved binding of the hydroxy-amine motif and the differences in the aromatic system moieties. Compounds are shown as sticks and surrounding residue side chains are shown as lines. Superscripts indicate the Ballesteros-Weinstein numbering convention.