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. Author manuscript; available in PMC: 2011 Aug 25.
Published in final edited form as: J Am Chem Soc. 2010 Aug 25;132(33):11768–11778. doi: 10.1021/ja1047363

Scheme 1a.

Scheme 1a

a Conditions: (a) 1. I2, KOH, MeOH; 2. KO2CN=NCO2K, AcOH, THF/i-PrOH, (62%); (b) CrO3/H5IO5, MeCN/H2O (9/1), (97%); (c) 1. COCl2, benzene; 2. 3a, collidine, CH2Cl2, –78 °C, (79%); (d) chlorodimethylvinylsilane, Et3N, CH2Cl2 (93%); (e) 6, benzene, rt (87%). The yields are of analytically pure material.